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CSRP2BP Rabbit pAb (bs-12947R)  
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50ul/1180.00元
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產品編號 bs-12947R
英文名稱 CSRP2BP Rabbit pAb
中文名稱 富含半胱氨酸蛋白結合蛋白抗體
別    名 ADA2A containing complex subunit 2; ADA2A-containing complex subunit 2; ATAC2; CRP2 binding partner; CRP2-binding partner; CRP2BP; CSR2B_HUMAN; CSRP2 binding protein; CSRP2-binding protein; Csrp2bp; Cysteine rich protein 2 binding protein; Cysteine-rich protein 2-binding protein.  
研究領域 心血管  細胞生物  信號轉導  轉運蛋白  表觀遺傳學  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 (predicted: Human,Mouse,Rat,Rabbit,Pig,Sheep,Cow,Dog,Horse)
產品應用 WB=1:500-2000,ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 89 kDa
檢測分子量
細胞定位 細胞核 細胞漿 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human CSRP2BP: 71-170/782 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 CRP2BP is a 782 amino acid protein encoded by the human gene CSRP2BP. CRP2BP specifically interacts with the double LIM domain protein CRP2. The LIM domain is a conserved cysteine and histidine-containing structural module of two tandemly arranged zinc fingers. It has been identified in single or multiple copies in a variety of regulatory proteins, either in combination with defined functional domains, like homeodomains, or alone, like in the CRP family of LIM proteins. Members of the cysteine- and glycine-rich protein family (CRP1, CRP2 and CRP3) contain two zinc-binding LIM domains, LIM1 (amino-terminal) and LIM2 (carboxyl-terminal), and are implicated in diverse cellular processes linked to differentiation, growth control and pathogenesis. Although present in cytoplasm, CRP2BP is mainly a ubiquitously expressed nuclear protein, with highest expression in skeletal muscle and heart.

Function:
Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. May function as a scaffold for the ATAC complex to promote ATAC complex stability. Has also weak histone acetyltransferase activity toward histone H4. Required for the normal progression through G1 and G2/M phases of the cell cycle.

Subunit:
Interacts with the LIM 1 domain of CSRP2. Component of the ADA2A-containing complex (ATAC), composed of CSRP2BP, KAT2A, TADA2L, TADA3L, ZZ3, MBIP, WDR5, YEATS2, CCDC101 and DR1. In the complex, it probably interacts directly with KAT2A, MBIP and WDR5.

Subcellular Location:
Nucleus. Cytoplasm. Mainly nuclear.

Tissue Specificity:
Expressed in skeletal muscle, heart, lung, placenta, brain, liver, pancreas and kidney. High expression in skeletal muscle and heart. Lower expression in lung.

Similarity:
Contains 1 N-acetyltransferase domain.

SWISS:
Q9H8E8

Gene ID:
57325

Database links:

Entrez Gene: 57325 Human

Entrez Gene: 228714 Mouse

SwissProt: Q9H8E8 Human

SwissProt: Q8CID0 Mouse

Unigene: 488051 Human

Unigene: 728790 Human

Unigene: 227925 Mouse



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