| 產品編號 |
bsk11065 |
| 英文名稱 |
Human sCD40L ELISA Kit
|
| 中文名稱 |
人可溶性CD40配體酶聯免疫試劑盒 |
| 別 名 |
TNFSF5; CD 154; CD154; CD 40L; CD154; CD154 antigen; CD40 homologue; CD40 ligand; CD40LG; gp39; hCD40L; HIGM1; Hyper IgM syndrome; IGM; IMD3; Ly62; T B cell activating molecule; T cell antigen GP39; TBAM; TNF related activation protein; TNF superfamily member 5; Tnfsf5; TRAP; Tumor necrosis factor (ligand) superfamily member 5. |
| 克 隆 號 |
|
| 種 屬 |
Human |
| 線性范圍 |
156 - 10,000 pg/mL |
| 應用范圍 |
S/P/CC |
| 檢測限 |
40 pg/mL |
| 適用樣品基質 |
cell culture supernates, serum, and plasma. |
| 保存條件 |
Store at 4°C & -20°C for 12 months. |
| 注意事項 |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 產品介紹 |
CD40 ligand (CD40L) is a 33 kDa type II membrane glycoprotein expressed mainly on the cell surface of activated T lymphocytes, but also exists as a soluble form extracellularly. CD40L is the ligand for CD40, a member of the TNF superfamily, which is expressed on the cell surface of B cells, macrophages/monocytes, dendritic cells, vascular endothelial cells, and epithelial cells. CD40L plays an important role in B cell proliferation, antibody class switching, modulation of apoptosis in the germinal center through interaction with B cells expressing CD40, and activation of CD4+ T cells. Mutation within the CD40L gene is linked to hyper IgM syndrome, an X linked immunodeficiency disease that is characterized by elevated level of serum IgM and decreased level of other isotypes.
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