97久久久精品综合88久久_亚洲国产精品一_久热热国产久热_97操操操_北条麻妃在线免费观看_精品国自产拍天天拍

掃碼關(guān)注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
动漫av在线,国产美女91呻吟求,99久久久精品视频
首頁 > 產(chǎn)品中心 > 標記一抗 > 產(chǎn)品信息
Rabbit Anti-PER1 protein/PE-Cy5.5 Conjugated antibody (bs-2350R-PE-Cy5.5)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-2350R-PE-Cy5.5
英文名稱 Rabbit Anti-PER1 protein/PE-Cy5.5 Conjugated antibody
中文名稱 PE-Cy5.5標記的節(jié)律抑制蛋白PER1抗體
別    名 Circadian clock protein PERIOD 1; Circadian clock protein PERIOD1; Circadian pacemaker protein Rigui; hPER 1; hPER; hPER1; KIAA0482; MGC88021; PER 1; PER; PER1; PER1 protein; PER1_HUMAN; Period 1; Period circadian protein homolog 1; Period drosophila homolog of; Period homolog 1; Period1; RIGUI.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領(lǐng)域 細胞生物  免疫學  染色質(zhì)和核信號  神經(jīng)生物學  表觀遺傳學  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Mouse,  (predicted: Human, Rat, Dog, Pig, Cow, Horse, Rabbit, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 136kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human PER1 protein
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
In mammals, several genes that encode members of the basic helix-loop helix (bHLH) PAS (PER-ARNT-SIM) transcription factor family have been shown to play a significant role in regulating circadian oscillations. Transactivation of CLOCK-induced genes is mediated via an E box enhancer (CACGTG) found upstream of target genes. CLOCK-ARNT 3 heterodimers bind to E box regulatory elements and stimulate gene transcription. CLOCK has been shown to transactivate the mammalian homolog of Drosophila PER. PER, in concert with the product of the mammalian timeless gene (TIM), negatively regulates its own transcription by blocking the activity of the CLOCK-BMAL 1 transactivation complex.

Function:
Component of the circadian clock mechanism which is essential for generating circadian rhythms. Negative element in the circadian transcriptional loop. Influences clock function by interacting with other circadian regulatory proteins and transporting them to the nucleus. Negatively regulates CLOCK|NPAS2-BMAL1|BMAL2-induced transactivation. Can bind heme (By similarity).

Subunit:
Component of the circadian core oscillator, which includes the CRY proteins, CLOCK or NPAS2, BMAL1 or BMAL2, CSNK1D and/or CSNK1E, TIMELESS, and the PER proteins. Interacts directly with TIMELESS, PER2, PER3 and, through a C-terminal domain, with CRY1 and CRY2. Interaction with CSNK1D or CSNK1E promotes nuclear location of PER proteins. Interacts with GPRASP1 (By similarity). Binding to CSNK1G2 triggers proteasomal degradation.

Subcellular Location:
Nucleus (By similarity). Cytoplasm (By similarity). Note=Mainly nuclear. Nucleocytoplasmic shuttling is effected by interaction with other circadian core oscillator proteins and/or by phosphorylation. Retention of PER1 in the cytoplasm occurs through PER1-PER2 heterodimer formation or by interaction with CSNK1E and/or phosphorylation which appears to mask the PER1 nuclear localization signal. Also translocated to the nucleus by CRY1 or CRY2 (By similarity).

Tissue Specificity:
Widely expressed. Found in heart, brain, placenta, lung, liver, skeletal muscle, pancreas, kidney, spleen, thymus, prostate, testis, ovary and small intestine. Highest level in skeletal muscle. Low level in kidney.

Post-translational modifications:
Phosphorylated on serine residues by CSNK1E. Also can be phosphorylated by the delta isoform. Phosphorylation by CSNK1 retains PER1 in the cytoplasm and leads to its ubiquitination and subsequent degradation.
Ubiquitinated (By similarity).

Similarity:
Contains 1 PAC (PAS-associated C-terminal) domain.
Contains 2 PAS (PER-ARNT-SIM) domains.

Database links:

Entrez Gene: 516318 Cow

Entrez Gene: 489488 Dog

Entrez Gene: 100731177 Guinea pig

Entrez Gene: 100073046 Horse

Entrez Gene: 5187 Human

Entrez Gene: 18626 Mouse

Entrez Gene: 100151739 Pig

Entrez Gene: 287422 Rat

Omim: 602260 Human

SwissProt: O15534 Human

SwissProt: O35973 Mouse

SwissProt: Q8CHI5 Rat

Unigene: 445534 Human

Unigene: 7373 Mouse

Unigene: 34433 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Per1蛋白的作用是機體生理節(jié)奏調(diào)節(jié)的核心基因,也是影響腫瘤發(fā)生發(fā)展的重要蛋白。調(diào)節(jié)機體生理節(jié)奏、調(diào)控細胞周期和促進DNA損傷修復等作用。Per1廣泛參與了細胞的周期調(diào)控、DNA損傷修復、細胞凋亡和腫瘤細胞增殖等過程
版權(quán)所有 2004-2026 m.kastlife.cn 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
主站蜘蛛池模板: 37人体做爰久久久久久 | 国产高清一级毛片在线不卡 | 五月天播播 | 一区视频免费观看 | 男人女人做爽爽18禁免费 | 久久伊人天堂 | 国产稚嫩高中生呻吟激情在线视频 | 久久久国产精品萌白酱免费 | 高潮毛片免费观看 | 国产9999精品| 91亚洲国产成人久久精品麻豆 | 日韩大片av| 久久一级黄色片 | 前夜40集连续剧免费观看国语高清 | 1024看片金沙日韩一区二区 | 色窝窝无码一区二区三区 | 精品护士一区二区三区 | 日本精品一二三 | 国产精品久久久久9999 | 亚洲成人黄色av | 精品亚洲一区二区三区在线观看 | 国产日本欧美视频 | 巨波霸乳在线永久免费视频 | 91视频.www| 精品国产丝袜自在线拍国语 | 草留视频 | 透逼视频 | 亚洲av极品无码专区亚洲av | 欧美日韩在线视频 | 免费在线观看亚洲视频 | 免费看黄视频在线观看 | 四虎国产成人 | 久草高清在线 | 人摸人人人澡人人超碰手机版 | 国产成熟女人性满足视频 | 网红主播大秀福利视频日韩精品 | 任你搞在线观看 | 久久国产热视频 | 国产精品VA在线观看老妇女 | 黑人巨大两根一起挤进 | 91九色超碰 |