97久久久精品综合88久久_亚洲国产精品一_久热热国产久热_97操操操_北条麻妃在线免费观看_精品国自产拍天天拍

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
伊人国产女,午夜精品视频网站,久久久天堂国产精品
首頁 > 產品中心 > 標記一抗 > 產品信息
Rabbit Anti-SP3/HRP Conjugated antibody (bs-7342R-HRP)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-7342R-HRP
英文名稱 Rabbit Anti-SP3/HRP Conjugated antibody
中文名稱 辣根過氧化物酶標記的轉錄因子SP3抗體
別    名 D130027J01Rik; DKFZp686O1631; GC binding transcription factor Sp 3; GC binding transcription factor Sp3; MGC105187; OTTMUSP00000014207; SP 3; Sp 3 transcription factor; SP3; Sp3 transcription factor; SP3_HUMAN; Specificity protein 3; SPR 2; SPR-2; SPR2; Transcription factor SP 3; Transcription factor SP3; Transcription factor Sp3.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 細胞生物  神經生物學  細胞周期蛋白  轉錄調節因子  表觀遺傳學  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Chicken, Cow, Rabbit, )
產品應用 WB=1:500-2000 ELISA=1:100-1000 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 82kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human SP3
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
The Sp transcription factor family includes Sp1, Sp2, Sp3 (SPR-2) and Sp4 (SPR-1). Sp transcription factors share similar structures but do not share simi-lar functions. All four proteins contain a highly conserved DNA-binding domain composed of three zinc fingers at the C-terminus. Sp family members bind the consensus sequence GGGGCGGGGC and other closely related sequences which are known as GC boxes. Sp1, Sp3 and Sp4 share a high affinity for GC boxes while Sp2 does not. Sp2 only weakly binds to GT boxes. Sp1, Sp2 and Sp3 are ubiquitously expressed, while Sp4 is abundantly expressed in brain with limited expression in other tissues. Sp1 and Sp3, but not Sp2 or Sp4, interact with E2, a regulatory element for the ∫4 subunit of neuronal nicotinic acetylcholine receptors. Sp3 is the only Sp member to inhibit Sp1 and Sp4 media

Function:
Transcriptional factor that can act as an activator or repressor depending on isoform and/or post-translational modifications. Binds to GT and GC boxes promoter elements. Competes with SP1 for the GC-box promoters. Weak activator of transcription but can activate a number of genes involved in different processes such as cell-cycle regulation, hormone-induction and house-keeping.

Subunit:
Interacts with HLTF; the interaction may be required for basal transcriptional activity of HLTF. Interacts with HDAC1; the interaction deacetylates SP3 and regulates its transcriptional activity. Interacts with HDAC2 (preferably the CK2-phosphorylated form); the interaction deacetylates SP3 and regulates its transcriptional activity. Interacts with MEIS2 isoform 4 and PBX1 isoform PBX1a.

Subcellular Location:
Nucleus. Nucleus > PML body. Localizes to the nuclear periphery and in nuclear dots when sumoylated. Some localization in PML nuclear bodies.

Tissue Specificity:
Ubiquitously expressed.

Post-translational modifications:
Not glycosylated.
Acetylated by histone acetyltransferase p300, deacetylated by HDACs. Acetylation/deacetylation states regulate transcriptional activity. Acetylation appears to activate transcription. Alternate sumoylation and acetylation at Lys-551 also control transcriptional activity. Ceramides can also regulate acetylation/deacetylation events through altering the interaction of HDAC with SP3. In vitro, C(18)-ceramides, but not C(16)-ceramides, increase the interaction of HDAC1 with SP3 and enhance the deacetylation of SP3 and the subsequent repression of the TERT promoter.
Sumoylated on all isoforms. Sumoylated on 2 sites in longer isoforms with Lys-551 being the major site. Sumoylation at this site promotes nuclear localization to the nuclear periphery, nuclear dots and PML nuclear bodies. Sumoylation on Lys-551 represses the transactivation activity, except for the largest isoform, L-Sp3, which has little effect on transactivation. Alternate sumoylation and acetylation at Lys-551 also control transcriptional activity.

Similarity:
Belongs to the Sp1 C2H2-type zinc-finger protein family.
Contains 3 C2H2-type zinc fingers.

Database links:

Entrez Gene: 6670 Human

Entrez Gene: 20687 Mouse

Entrez Gene: 367846 Rat

Omim: 601804 Human

SwissProt: Q02447 Human

SwissProt: O70494 Mouse

Unigene: 531587 Human

Unigene: 124328 Mouse

Unigene: 446209 Mouse

Unigene: 465887 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權所有 2004-2026 m.kastlife.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: 精品一区欧美 | 新版天堂资源中文www官网 | 老子影院午夜伦不卡 | 久久视频这里只精品 | 啊灬啊灬快灬高潮了视频 | 经典老熟女ass | 亚洲日本乱码一区二区三区 | 久草在线免费在线观看 | 日本欧美一区二区三区高清 | 国产一区久久精品 | 欧美日韩精品一区二区三区四区 | 国产精品成人亚洲一区二区 | 亚洲国产AV天码精品果冻传媒 | 久久精品国产精品国产精品污 | 藏精阁成人免费观看在线视频 | 人妻少妇精品视频二区 | 新版天堂资源中文www官网 | 完全着衣の爆乳お姉さんが | 在线啪啪 | 国产强伦姧人妻毛片 | 38激情网 | 国产AV无码专区亚洲AV毛网站 | WWW国产精品内射老师 | 办公室扒开奶罩揉吮奶头AV | 色婷婷av一区二区三区软件 | xxxx黄色片 | 人伦人与牲囗免费观看 | 午夜一级黄色大片 | 国产精品色婷婷99久久精品 | 免费黄在线观看 | 99久久夜色精品国产亚洲av卜 | 欧美亚洲国产精品久久高清 | 久久综合久久综合九色 | 亚洲精品久久久久久久久久 | 激情亚洲一区国产精品 | 青草综合一区二区三区 | 天天干天天摸天天操 | 斗罗大陆3龙王传说第四季免费观看 | 日韩精品一区二区三区蜜臀 | 女人被男人桶爽视频网站 | 午夜精品一区二区三区三上悠亚 |