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Rabbit Anti-EHD2/BF350 Conjugated antibody (bs-14526R-BF350)
訂購熱線:400-901-9800
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訂購QQ:  400-901-9800
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-14526R-BF350
英文名稱 Rabbit Anti-EHD2/BF350 Conjugated antibody
中文名稱 BF350標(biāo)記的EHD2蛋白抗體
別    名 EH domain containing 2; EH domain containing 3; EH domain containing protein 2; EH domain-containing protein 2; EHD 2; Ehd2; EHD2_HUMAN; EHD3; FLJ96617; PAST 2; PAST homolog 2; PAST2.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領(lǐng)域 細胞生物  結(jié)合蛋白  表觀遺傳學(xué)  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, )
產(chǎn)品應(yīng)用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 60kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human EHD2
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
This gene encodes a member of the EH domain-containing protein family. These proteins are characterized by a C-terminal EF-hand domain, a nucleotide-binding consensus site at the N terminus and a bipartite nuclear localization signal. The encoded protein interacts with the actin cytoskeleton through an N-terminal domain and also binds to an EH domain-binding protein through the C-terminal EH domain. This interaction appears to connect clathrin-dependent endocytosis to actin, suggesting that this gene product participates in the endocytic pathway. [provided by RefSeq, Jul 2008]

Function:
Plays a role in membrane reorganization in response to nucleotide hydrolysis. Binds to liposomes and deforms them into tubules. Plays a role in membrane trafficking between the plasma membrane and endosomes. Important for the internalization of GLUT4. Required for normal fusion of myoblasts to skeletal muscle myotubes. Binds ATP; does not bind GTP.

Subcellular Location:
Cell membrane. Endosome membrane. Colocalizes with GLUT4 in intracellular tubulovesicular structures that are associated with cortical F-actin.

Tissue Specificity:
Highly expressed in heart and moderately expressed in placenta, lung, and skeletal muscle.

Similarity:
Contains 1 EF-hand domain.
Contains 1 EH domain.

Database links:

Entrez Gene: 30846 Human

Entrez Gene: 538348 Cow

Entrez Gene: 259300 Mouse

Entrez Gene: 361512 Rat

Omim: 605890 Human

SwissProt: Q9NZN4 Human

SwissProt: Q8BH64 Mouse

SwissProt: Q4V8H8 Rat

Unigene: 631554 Human

Unigene: 138215 Mouse

Unigene: 438817 Mouse

Unigene: 16016 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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