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Rabbit Anti-EMG1/Gold Conjugated antibody (bs-14579R-Gold)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul(10nm  15nm  35nm
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-14579R-Gold
英文名稱 Rabbit Anti-EMG1/Gold Conjugated antibody
中文名稱 膠體金標記的EMG1蛋白抗體
別    名 18S rRNA (pseudouridine-N1-)-methyltransferase NEP1; 18S rRNA Psi1248 methyltransferase; C2F; C2f protein; EMG 1; EMG1; EMG1 N1 specific pseudouridine methyltransferase; EMG1 nucleolar protein homolog (S cerevisiae); EMG1 nucleolar protein homolog; essential for mitotic growth 1; FLJ60792; Grcc2f; NEP1; NEP1_HUMAN; Nucleolar protein EMG1 homolog; Protein C2f; Ribosomal RNA small subunit methyltransferase Nep1; Ribosome biogenesis protein NEP1.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul(10nm  15nm  35nm
研究領(lǐng)域 細胞生物  發(fā)育生物學  神經(jīng)生物學  轉(zhuǎn)錄調(diào)節(jié)因子  表觀遺傳學  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
產(chǎn)品應(yīng)用 IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 27kDa
性    狀 Lyophilized or Liquid
濃    度 0.4mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human EMG1
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300.
保存條件 Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles.
產(chǎn)品介紹 background:
This gene encodes an essential, conserved eukaryotic protein involved in ribosome biogenesis. In yeast, the related protein is a component of the small subunit processome and is essential for biogenesis of the ribosomal 40S subunit. A mutation in this gene has been associated with Bowen-Conradi syndrome.[provided by RefSeq, May 2010]

Function:
Involved in 40S ribosomal subunit biogenesis and 18S rRNA processing. Specifically catalyzes the N1-methylation of pseudouridine at position 1248 (Psi1248) in 18S rRNA. Thus, appears to be the methyltransferase involved in the biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) in position 1248 in 18S rRNA. Is not able to methylate uridine at this position.

Subcellular Location:
Nucleus > nucleolus.

DISEASE:
Defects in EMG1 are the cause of Bowen-Conradi syndrome (BWCNS) [MIM:211180]. BWCNS is a combination of malformations characterized in newborns by low birth weight, microcephaly, mild joint restriction, a prominent nose, micrognathia, fifth finger clinodactyly, and 'rocker-bottom' feet. The syndrome is transmitted as an autosomal recessive trait. The prognosis is poor, with all infants dying within the first few months of life.

Similarity:
Belongs to the NEP1 family.

Database links:

Entrez Gene: 10436 Human

Entrez Gene: 515362 Cow

Entrez Gene: 477708 Dog

Entrez Gene: 100722865 Guinea pig

Entrez Gene: 100052984 Horse

Entrez Gene: 14791 Mouse

Entrez Gene: 100627558 Pig

Entrez Gene: 312706 Rat

Omim: 611531 Human

SwissProt: Q92979 Human

SwissProt: O35130 Mouse

Unigene: 558447 Human

Unigene: 273915 Mouse

Unigene: 6390 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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