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Rabbit Anti-NAB1/PE Conjugated antibody (bs-18994R-PE)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-18994R-PE
英文名稱 Rabbit Anti-NAB1/PE Conjugated antibody
中文名稱 PE標記的EGR1結合蛋白1抗體
別    名 EGR 1 binding protein 1; EGR-1-binding protein 1; EGR1 binding protein 1; NAB1; NAB1_HUMAN; NGFI A binding protein 1 (EGR1 binding protein 1); NGFI A binding protein 1; NGFI-A-binding protein 1; Transcriptional regulatory protein p54.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 細胞生物  轉錄調節因子  表觀遺傳學  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Chicken, Pig, Cow, Horse, Rabbit, Sheep, )
產品應用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 54kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human NAB1
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
Transcriptional control is in part regulated by interactions between DNA-bound transcription factors, such as Egr1/NGFI-A, and coregulatory proteins, such as NAB (for NGFI-A-binding proteins). The evolutionarily conserved NAB proteins, NAB1 and NAB2, are corepressors of Egr1/NGFI-A. Both NAB1 and NAB2 contain an amino-terminal NAB-conserved domain 1 (NCB1), which is required for binding NGFI-A, and a carboxy-terminal NCD2, which is responsible for the repressor function of NAB proteins. NAB1 requires NGFI-A to gain access to DNA, indicating that NAB1 is an active repressor that works by a direct mechanism. NAB1, which is constitutively expressed, is localized exclusively in the nucleus and may play a role in controlling processes such as cell division, differentiation and apoptosis.

Function:
Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2.

Subcellular Location:
Nucleus.

Tissue Specificity:
Isoform Short is found in a myeloid leukemia cell line.

Similarity:
Belongs to the NAB family.

Database links:

Entrez Gene: 4664 Human

Entrez Gene: 17936 Mouse

Entrez Gene: 64824 Rat

Omim: 600800 Human

SwissProt: Q13506 Human

SwissProt: Q61122 Mouse

SwissProt: Q62722 Rat

Unigene: 723892 Human

Unigene: 25903 Mouse

Unigene: 10099 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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