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Rabbit Anti-PRDM5/BF488 Conjugated antibody (bs-19955R-BF488)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-19955R-BF488
英文名稱 Rabbit Anti-PRDM5/BF488 Conjugated antibody
中文名稱 BF488標記的PR結構域鋅指蛋白5抗體
別    名 BCS2; PFM 2; PFM2; PR domain containing 5; PR domain containing protein 5; PR domain zinc finger protein 5; PR domain-containing protein 5; PRDM 5; PRDM5; PRDM5 protein; PRDM5_HUMAN.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 細胞生物  轉錄調節因子  鋅指蛋白  表觀遺傳學  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, Sheep, )
產品應用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 73kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human PRDM5
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
The protein encoded by this gene is a transcription factor of the PR-domain protein family. It contains a PR-domain and multiple zinc finger motifs. Transcription factors of the PR-domain family are known to be involved in cell differentiation and tumorigenesis. [provided by RefSeq, Jul 2008]

Function:
Sequence-specific DNA-binding transcription factor. Represses transcription at least in part by recruitment of the histone methyltransferase EHMT2/G9A and histone deacetylases such as HDAC1. Regulates hematopoiesis-associated protein-coding and microRNA (miRNA) genes.

Subunit:
Interacts with EHMT2/G9A, GFI1 and HDAC1.

Subcellular Location:
Nucleus.

Tissue Specificity:
Widely expressed with highest levels in colon and ovary. Tends to be silenced in breast, colorectal, gastric and liver cancer tissues.

DISEASE:
The disease is caused by mutations affecting the gene represented in this entry.
Disease description:A disorder characterized by extreme corneal thinning resulting in corneal rupture after minor trauma, blue sclerae, keratoconus or keratoglobus, hyperelasticity of the skin, and hypermobile joints.

Similarity:
Contains 16 C2H2-type zinc fingers.
Contains 1 SET domain.

Database links:

Entrez Gene: 11107 Human

Entrez Gene: 70779 Mouse

Entrez Gene: 689788 Rat

Omim: 614161 Human

SwissProt: Q9NQX1 Human

SwissProt: Q9CXE0 Mouse

Unigene: 666782 Human

Unigene: 669312 Human

Unigene: 263355 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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